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This temporal pattern peak during escalation, partial decline at maintenance, full reversal after stopping is predictable and manageable
Clinical trial data have not established a direct causal link between semaglutide and muscle pain, though symptoms may relate to rapid weight loss, changes in body composition, nutritional factors, or increased physical activity
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Endocrinology , 166 (2), bqae165
But it does so in an episodic manner
In the STEP 1 trial, the overall average was 15% over 68 weeks
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