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Stacked on top of insulin or a sulfonylurea it can, and the lever is de-intensifying that background drug, not lowering the tirzepatide dose. Over-loss in low-BMI deep responders Across the obesity trials, about 7% of participants fell below a BMI of 22, some by week 12
Fernandez-Checa JC, Yi J-R, Garcia-Ruiz C, Knezic Z, Tahara SM, et al
Sosne, G., Rimmer, D., Kleinman, H., & Ousler, G
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