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Cys151 residue is required to inhibit Keap1-mediated Nrf2 degradation, thus itaconate upregulates Nrf2 levels via Keap1 alkylation ( Figure 3 )

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Furthermore, the concomitant rate of auto-oxidation of doxorubicin within the cell is assumed to be equal to that of the OCR experimental data used to parameterise the model

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Lactate dehydrogenase in the synovial tissue in rheumatoid arthritis: total activity and isoenzyme composition