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The SEMA injection (1.34 mg/mL 1.5 mL Novo Nordisk, China) was diluted by 0.9% sodium chloride into a 0.02-mg/mL working liquid and then stored in refrigerator at 4C away from light

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Am J Med 118(5):2734 Polonsky W, Fisher L, Hessler D, Bruhn D, Best J (2011) Patient perspectives on once-weekly medications for diabetes

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Combination therapy The underlying pathophysiology of type 2 diabetes is complex, with multiple contributing abnormalities resulting in a naturally progressive disease and increasing HbA 1c over time in many

The knock-in efficiency was determined using the equation: Knock-in (%) = (Copy number of target)/(Copy number of reference + Copy number of target) 100