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Our clinical experience shows optimal benefits occur within the 100-250 mcg range for most applications
Weibull distribution modeling characterized failure patterns of time-to-onset data, where the shape parameter () defined three scenarios: the upper limit of 95% confidence interval (CI) of 1 (wear-out failure: risk escalation with prolonged use) 22 (Table S4)
B12 is a cofactor for the enzyme, methylmalonyl-CoA mutase, which transforms methylmalonyl-CoA into succinyl-CoA, which the body can directly use in the Krebs cycle to produce ATP
After 3-5 days, increase to 0.5 mg if tolerated
No way to verify dose, purity, or contamination
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