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Microplastics have been detected in aquatic and terrestrial ecosystems, with polyethylene microplastics accounting for more than 50% of total microplastics floating in the ocean (Issac and Kandasubramanian, 2021), thus representing a risk for multiple species and human health (Li et al., 2023)
On the basis of results of the most recent CVOTs (DAPA-HF, DAPA-CKD, EMPEROR-R), the FDA has approved dapagliflozin (2020) and empagliflozin (2021) to reduce risk for CV death and HF hospitalization in adults with HF and reduced ejection fraction regardless of whether they have diabetes [24, 25]
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