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Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility

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Given that retatrutide is not yet approved for clinical use in the UK, the most appropriate course of action for any woman interested in this treatment is to speak with her GP or a specialist in a Tier 3 or Tier 4 weight management service, or an endocrinology or diabetes team

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