Zero-order kinetics are a dosing nightmare
However, those with significantly restricted intake, persistent gastrointestinal symptoms, or pre-existing nutritional concerns may benefit from targeted assessment
This is not unheard of, as drugs like pioglitazone and acipimox both reduce metabolic complications without treating obesity at all
Medical supervision helps make sure you are not relying on hype or guesswork
A key proposed advantage of AOD 9604 over full hGH is that it lacks the diabetogenic effects associated with hGH's IGF-1 and anti-insulin signaling
Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities