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N Engl J Med 377:839848 Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR et al (2019) Oral semaglutide and cardiovascular outcomes in patients with type 2 diabetes
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A Phase 2 trial (a mid-stage human trial, typically involving a few hundred participants) published in the New England Journal of Medicine in 2023 reported an average weight loss of about 24% at 48 weeks with the highest dose
The lipid conjugate is the principal driver of albumin binding in plasma-stability assays
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