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It is important to note that internalized nanoscale materials, including citrate-coated Ag NPs [453], polyvinylpyrrolidone-coated Ag NPs [453], and Si NPs [458], trigger eryptosis in a Ca 2+ -, ROS-, and calpain-mediated fashion (Fig

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However, under conditions where mitochondrial superoxide production is inhibited, alternate pathways can activate caspase 3 cleavage to shift cell death to apoptosis in a subset of hepatocytes

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Suitable for daily use as part of a healthy lifestyle