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[9] [10] This extended elimination period provides a built-in "taper" effect, allowing the body to adjust as drug concentrations decline progressively rather than precipitously

Of note, Aravindhan et al

Furthermore, the integration of temporal and spatial omics profiling may enable dynamic monitoring of signaling rewiring, informing the design of context specific, resistance-preemptive regimens

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Pickart & Margolina's 2018 review reported modulation of approximately 4,000 human genes in cultured cells [16]