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3 While the study could not prove the drugs directly caused these problems, the authors noted that rapid drops in blood sugar triggered by treatment could have contributed to the vision loss observed

Accordingly, the American Diabetes Association recommends the use of GLP-1RAs with or without metformin in patients with atherosclerotic cardiovascular disease (ASCVD), chronic kidney disease (CKD), and/or heart failure (HF) [25]

Oxidative Stress Evidence: Teranishi M, Uchida S, Nishio N, et al

Diabetologia (2017) 60:17319

Since a substantial portion of dAGEs in food is bound to proteins, this suggests that proteolytic digestion may play a role in their breakdown and some human digestive enzymes, such as elastase, trypsin, and chymotrypsin, are likely to contribute to the degradation of protein-bound dAGEs (105107)

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