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Relative to glimepiride (sulfonylurea), DPP-4i were not associated with any increase in cardiovascular risk for patients with T2DM [58]
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Sublingual: The emulsion behavior in the saliva may support solubility and dispersion
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O mesmo estudo observou que a suplementao com cistena e glicina pode restaurar os nveis de glutationa em idosos a patamares semelhantes aos de jovens saudveis
As an example, in the DURATION-8 study, while combination therapy produced greater HbA1c and body weight reductions, the effect was less than additive compared to the sum of individual drug effects, most likely because the efficacy of glucose-lowering therapies can depend on baseline glycaemic control [24]
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