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In DFO-treated parasites, while some overlap with DHA-induced genes (e.g., merozoite-related functions) was observed at later stages, unique transcriptional changes were also evident, such as upregulation of genes involved in chromatin organization, protein-DNA complex assembly, nucleosome dynamics, regulation of RNA polymerase II-mediated transcription initiation, and regulation of protein catabolic processes

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Oxidative stress is represented in the model by the concentration of H 2 O 2

6 Extracellular acidification of gsh2 mutants is independent of l-DOPA and GSH pathway metabolites influence melanin formation