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Weight loss during this phase averages 3-6 lbs, though much of this represents water and glycogen depletion rather than fat loss
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The Reason: Semaglutide provides biological appetite suppression, whereas intermittent fasting relies on behavioral discipline to manage hunger, which often leads to "overcompensation" (eating too much) during the feeding window
Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response
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