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77 th American Diabetes Association 2017 Scientific Sessions
Mutations identified in patients with defective lipoic acid metabolism affect genes involved in the synthesis of iron-sulfur clusters and genes coding for lipoic acid synthetase ( LIAS ), lipoyl transferase 1 ( LIPT1 ), and dihydrolipoamide dehydrogenase (E3 component of -ketoacid dehydrogenase complexes
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Hepatic Safety Hepatic safety has been a particular focus of attention for orforglipron given the hepatotoxicity findings that led to the discontinuation of two competing oral small-molecule GLP-1 programs
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S.YahyaG.ZimmermannJ.MaiM.MergelS.MhlhausT.et al (2021)
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