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Side effects and medical concerns Muscle Loss: A meaningful portion of the weight loss is coming from muscle mass, which can be harmful, especially for older adults or frail individuals

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45 A similar benefit was shown in analyses by baseline KCCQ-CSS tertiles, BMI, and LVEF subgroups

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Johnstone AM, Murison SD, Duncan JS, Rance KA, Speakman JR: Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine

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