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Previous studies confirmed that APAP induced nuclear enrichment of Yes-associated protein (YAP) in hepatocytes [37] and hepatocyte-specific deletion of YAP led to faster recovery from AILI [38]

The concern is theoretical and mechanistic: Dihexa's proposed action is potentiation of hepatocyte growth factor (HGF) signaling at the c-Met receptor, a growth, proliferation, and angiogenesis pathway that is dysregulated in several cancers

1.8% of diabetic patients taking other medications received a NAION diagnosis

This neuroanatomical overlap raises the possibility of vagus nerve disorders, though causal mechanisms require further elucidation

doi: 10.1016/0167-4889(94)90250-x 32 ManMQLinTKSantiagoJLCelliAZhongLHuangZMet al

doi: 10.1186/s12943-024-01999-9 102