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Retatrutide, a triple agonist in Phase 3 clinical trials, produced average weight loss of 24 percent at 48 weeks in Phase 2 data (Jastreboff et al., NEJM , 2023)

But the margin between 'effective' and 'side effects dominate the experience' is narrow

Do not buy GLP-1 drugs from unregulated online marketplaces

It doesnt elevate prolactin or cortisol that much, so side effects like water retention or mood swings are uncommon

For some, it might also offer direct cardiovascular benefits, but it is not a primary blood pressure medication Q: Do I need to stop my blood pressure medication if I start Ozempic

Williams LM (2012) Hypothalamic dysfunction in obesity