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To investigate the role of DD2R in obesity, researchers examined the association between body mass index (BMI) and a specific genetic variation called the Taq1A polymorphism, which is linked to lower DD2R levels and increased risk for drug addiction

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Role of GLP-1R binding kinetics The length of time that an agonist remains bound to its receptor, or residence time, is an important factor influencing the duration of drug action and a suggested driver of sustained signaling from internalized receptors 7

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