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First, How does a GLP-1 help with weight loss

Lancet 397 , 17361748 (2021)

However, despite the anti-diabetic and anti-obesity functions, of these dual and triple agonists, the long-term safety, cardiovascular, and renal benefits of these multi-target therapies need further validation

The problem inherently is that were not quite sure what it is that causes all this benefit

Conclusion: A New Approach to Stubborn Fat 5-amino-1MQ represents a fundamentally different approach to fat loss

Inhibition of mitochondrial adaptations and improvements in cardiorespiratory fitness by 50 percent and diminished whole-body insulin sensitivity after aerobic exercise 6 Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults Konopka et al (2018)