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Alongside weight loss, the trial showed improvements in physical function and across a spread of cardiometabolic risk factors: waist circumference, HbA1c, fasting glucose, lipid profile, blood pressure, and C-reactive protein (Wharton et al., 2025)

Both share common side effects and serious boxed warnings from the FDA

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Glucose markers (HbA1c, fasting glucose) typically begin rising within 4-8 weeks of discontinuation

EAC=external adjudication committee