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Another class of promising antioxidants consists of glutathione peroxidase mimetics, among which ebselen exhibits favorable oral tolerance and bioavailability

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This causes them to stretch and swell, which may make them appear larger, temporarily

The 'LR3' designation refers to a 13-amino-acid N-terminal extension and a glutamic acid substitution at position 3, which together reduce binding affinity for IGF-binding proteins (IGFBPs) by approximately 100-fold

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It activates TrkB receptors and induces downstream signaling pathways that promote cell survival, growth, differentiation and plasticity