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Why GIP Was Initially Controversial Early studies in people with type 2 diabetes found that their insulin response to GIP was diminished compared to people without diabetes

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Diabetologia 54 , 1018 (2011)

Interestingly, in people with type 2 diabetes mellitus, who often exhibit glomerular hyperfiltration, GLP-1 receptor agonists stabilize or modestly reduce eGFR, an effect reminiscent of the initial declines observed with RAAS and SGLT2 inhibitors [64]

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