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In an accompanying editorial, Janani Rangaswami, MD (Washington DC Veterans Affairs Medical Center), and colleagues say the findings represent a key opportunity to intensify CV-kidney therapies in real-world practice in high-risk CKD even without overt CVD being present, given comparable event rates and benefits from therapies. The numbers needed to treat to prevent one primary kidney outcome at 3 years amounted to 22 in those with ASCVD, 13 in those with HF, and 17 in those with a PREVENT score 20%