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Thymosin beta-4 itself is the major G-actin (monomeric actin)sequestering peptide in mammalian cells
2.1.3 Enzyme responsive hydrogels In the osteoarthritic inflammatory microenvironment, mediators activate NF-B and MAPK signaling and sustain high expression of matrix-degrading enzymes, notably MMPs (including MMP-13) and ADAMTS
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Kroemer, G
The lethal concentration (LC 50 ) for HThF cells was ~ 1 M, while the LC 50 for the PTC cell lines was substantially less (0.050.5 M)
However, the authors stated this is not a clinically significant difference
