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Eli Lillys triple hormone receptor agonist cut body weight by 26.6% on a placebo-adjusted basis and reduced knee osteoarthritis pain by 75%, capping off a trio of wildly successful readouts for the pharmas obesity pipeline

Pregnancy Use: Its not known whether its safe to use semaglutide during pregnancy

Common (and Manageable) Side Effects Most side effects associated with PT-141 are temporary and tend to resolve on their own

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Your provider should be your primary decision-maker here, informed by the data we will cover throughout this guide

For context on why dosing matters for this peptide, see our GLP-3 peptide guide which explains retatrutide's mechanism