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Individual response varies widely even though the mechanisms are well characterized, which is why trial averages describe groups rather than what any one person will experience

Factors That Slow Results Inconsistent Dosing Missing multiple doses, taking injections on varying days, or stopping and restarting treatment reduces total effectiveness

Earlier studies using these mice include (5-7, 101)

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10.1016/S0140-6736(85)91481-3 Ohtani Y, Endo F, Matsuda I: Carnitine deficiency and hyperammonemia associated with valproic acid therapy

Total N = 6 750, sample size per each cohort/ancestry can be found in Table 1