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For more than 50 years metformin has been used to control hyperglycaemia in patients with type 2 diabetes, and it is currently recommended as the first-line drug treatment along with lifestyle modification [1]
10.1186/s13063-019-3259-x 23 FredborgM.TheilP
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However, its important to note that this study showed an association, not necessarily causation
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At the same time, history offers numerous examples of treatments that appeared promising early on but later revealed safety concerns, unexpected adverse effects, or limited long-term benefit
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