GLP-1 slows gastric emptying, enhances insulin secretion, suppresses glucagon, and directly signals satiety centers in the hypothalamus (Wilding et al., 2021)
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It also improves insulin secretion and glucose control
[16] DPP-4 inhibitors (such as sitagliptin), which enhance incretin activity through a different mechanism Insulin therapy, particularly if oral agents and other injectables are unsuitable Traditional agents like metformin, sulphonylureas, or pioglitazone, depending on individual circumstances NICE guideline NG28 recommends individualised treatment approaches based on HbA1c targets, cardiovascular risk, renal function, and patient preferences
By meeting this demand, providers can offer holistic, patient-centered care that addresses both the psychological and physical aspects of weight management
JACC 84(1):2740 Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
