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The GHR-Independent Signaling Cascade After subcutaneous injection, AOD-9604 appears to act on adipocytes through pathways that overlap with beta-adrenergic and peroxisome-proliferator-activated receptor (PPAR) signaling
however, the clinical relevance of this finding is unclear and requires further investigation before conclusions can be drawn
The reasons for these failures often include short in vivo half-life, chemical instability, limited cellular uptake, poor bioavailability, lack of targeted delivery to specific tissues or (sub)cellular compartments, a narrow therapeutic index, and toxicity
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