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Some people find that constipation improves when switching from tirzepatide, while others experience worsening as semaglutide doses increase
The research shows weight loss of 10 to 12 percent with cagrilintide alone, and when combined with semaglutide in the CagriSema protocol , results exceed 22 percent body weight reduction over 68 weeks
So if you are feeling a sense of urgency or firmly want to get started, the risk of delaying other effective treatments (see below) until the duration of the study is completed may not be worth it
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