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Mitochondrial dysfunction and apoptotic pathways Mitochondria-rich hair cells are particularly vulnerable to toxic insults

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In fact, folic acid in particular can be problematic for anyone with an MTHFR mutation

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It is important to distinguish between urinary changes related to GLP-1 therapy and those caused by other diabetes medications, particularly SGLT2 inhibitors (such as dapagliflozin, empagliflozin), which do directly increase urination as their primary mechanism of action

That matters because both estrogen deficiency and polycystic ovary syndrome (PCOS) can make it easier to store fat in the liver