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While studies in the meta-analysis described above excluded patients with a history of gallstones, clinical outcomes showed that higher doses and longer periods of use with GLP1-RAs have been associated with the greatest risk

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Many patients find they can continue enjoying moderately spiced meals without difficulty, whilst others discover that foods they previously tolerated well now cause discomfort

5 Moreover, GLP-1 RAs have demonstrated cardioprotective properties that are independent of weight loss by reducing the content of systemic inflammation markers

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