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A 2024 study, for example, found that while GLP-1 therapy alone was associated with reduced bone mineral density at the hip and spine, adding resistance exercise appeared to fully offset that loss, Splenser noted
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Tirzepatide targets both GLP-1 and GIP receptors
The safety profile so far looks consistent with other approved GLP-1 drugs, with no new red flags
Or better yet, simply let it sit
In 2025, the American Association of Clinical Endocrinology updated its Obesity Algorithm, which highlights the importance of preserving skeletal muscle during medical weight-loss interventions: patients who retain strength tend to experience fewer side effects, more energy, and better long-term weight maintenance
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