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After activation by full agonists such as GLP-1, GLP-1R couples with Gs, activates adenylate cyclase (AC), and causes the accumulation of cAMP

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Side effects are rare and typically mild, such as slight discomfort at the injection site or temporary bruising

CVOT trials help to investigate whether a new drug has a positive or negative impact on cardiovascular events

Participants also experienced reductions in total body fat (up to 9%), visceral fat (up to 24%), and subcutaneous fat (up to 9%), alongside an increase in skeletal muscle (up to 6%)