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Immunomodulatory glycan lnfpiii alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways

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All results of the in vitro albumin binding studies and animal pharmacokinetic studies described here are consistent with and support the hypothesis of competition between icodec and semaglutide for albumin binding occurring locally at the injection site in the subcutaneous tissue such that icodec outcompetes semaglutide (Fig