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This is due to the fact that in CGD the production of the ROS, hydrogen peroxide, is deficient and so these catalase-positive microorganisms can defeat the limited levels of ROS produced by phagocytic cells

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Its ability to mimic the hormone glucagon-like peptide-1 (GLP-1) is crucial in regulating appetite and food intake

For instance, overconsumption of Omega-6 fatty acids in C57BL/6 J mice increased Proteobacteria populations and macrophage infiltration in adipose tissue [164]

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This variability can impact clinical trial outcomes and pose difficulties in designing broadly applicable therapeutic protocols (Xiong et al., 2023)