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Factors such as temperature, pH, oxygen, light, and metal ions can significantly accelerate this oxidation process

The first column of Table 5 shows the average percent change in the levels of six plasma metabolites in 42 Down patients compared to controls (taken from [13])

Vermoote, M

Ozek, C., Krolewski, R

Decreased erythropoietin (EPO) production, shortened erythrocyte survival, and other factors reducing the response to EPO contribute to anemia in patients with a variety of underlying pathologies such as chronic kidney disease (CKD)