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To put that in perspective, the best semaglutide clinical trials showed approximately 15-17% weight reduction, and tirzepatide results peaked around 20-22%

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However, the body weight of 5A-1MQ-treated obese mice (WD/LD-T group), which was indistinguishable from the other DIO groups at study start, was indistinguishable from the lean control (LD/LD-V) group at study completion (results with FDR correction

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