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GLP-1 therapies like Semaglutide and Tirzepatide are FDA-approved for managing weight loss and supporting diabetes care
Gastroenterology (2017) 153(2):4209
(2023) GLP-1/glucagon receptor co-agonism for treatment of obesity Diabetologia 66(7):1281-1294
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Side effects reported in clinical trials have included: gastrointestinal symptoms possible increases in heart rate changes in body composition during rapid weight loss metabolic or hormonal adjustments These findings are part of the reason the medicines remain under active investigation
In the glucocorticoid-induced osteoporosis (GIOP) rat model, administration of liraglutide at a dose of ~ 53 nmol/kg/day did not result in significant weight loss [59]
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