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However, retatrutide was not completely without effects in the mouse atrium

Am J Med Genet B Neuropsychiatr Genet 2006

According to the Cleveland Clinic, slowing digestion is part of how GLP-1s workwhich means that small, easy-to-digest meals are often better tolerated

Weight loss timeline on retatrutide 12mg (Phase 2 data) Weeks 148: Phase 2 data (Jastreboff 2023, 12mg group)

But in some people, they may also prompt bouts of vomiting that can require medical attention and slow the stomach so much that they can lead to a condition called gastroparesis