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Tapering and discontinuation considerations

Richfield et al

[9] GST-Pi is expressed in many human tissues, particularly in the biliary tree, renal distal convoluted tubules and lungs

Injection site reactions (15-25%), occasional nausea (5-10%), and rare dizziness (3-7%) are the most commonly reported issues, and these typically resolve within hours to days without treatment

Mice were euthanized on the last day of treatment

Disruptions to the synthesis, recycling, or cellular distribution of GSH are prominent observations that exist in multiple neurodegenerative diseases, suggesting a possible route of therapeutics that could facilitate treatment of these conditions