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Considering the ongoing shortage of injectable incretin-based therapies, future research should aim to prioritize randomized controlled trials evaluating the efficacy of oral semaglutide in patients without diabetes, as well as include a broader demographic spectrum, integrate pharmacological treatment with structured non-pharmacological interventions and improve control over potential confounders, especially those related to lifestyle
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That brings us to the second and arguably most urgent issue facing the field: the complete absence of validated biomarkers for patient selection, durability prediction, inflammation trajectories, neuroprotective potential, or combination-therapy optimization
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