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Stephens FB et al
(Lond.) 41 (11), 16071614
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GI side effects and therapeutic effectiveness are both driven by the same mechanism of action
The clinical principle is start low and go slow. Your dose should escalate based on how you are tolerating it, not on a manufacturers pre-set schedule
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![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
