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72 CAR T-cell therapy directly targets tumor surface antigens via engineered CARs, completely bypassing the tumor cell-intrinsic MHC class I antigen presentation pathway, whereas CAR-NK cell therapy integrates CAR-directed cytotoxicity with the innate missing-self recognition of NK cells, enabling efficient elimination of tumor cells with downregulated or absent MHC class I expression and thereby directly addressing resistance mechanisms

According to the public registry, the trial was completed, and the results suggest a favorable safety profile with no significant adverse events reported (ClinicalTrials.gov Identifier: NCT03416053)

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