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Presented for research literature review only Verhulst ML et al

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Association of angiotensin IIstimulating antihypertensive use and dementia risk: post hoc analysis of the PreDIVA trial

The mechanism involves clearance of senescent Leydig cells that secrete pro-inflammatory SASP factors (IL-1, IL-6, TGF-) which impair testosterone production in neighboring healthy cells

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This range helps doctors tailor treatments based on how bad the deficiency is and how well the patient responds