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Is dietary compliance consistent

In addition, the dual mechanism of action on GLP-1 and GIP receptors seems to potentiate the effect on satiety, insulin sensitivity and postprandial glucose control, which may explain the magnitude of the results

Gastrointestinal side effects were the most common adverse events, leading to therapy discontinuation in some cases

The SURMOUNT-1 trial, published in the New England Journal of Medicine, randomized 2,539 adults with obesity or overweight to tirzepatide 5 mg, 10 mg, or 15 mg weekly for 72 weeks

This slow, sustained release mechanism offers two distinct clinical advantages

[22] [23] 4 mg (TA875) and tirzepatide for weight management, which set out the eligibility criteria for these licensed medicines