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Efficacy studies have demonstrated this additive effect with metformin, sulfonylureas, and thiazolidinediones given in combination with saxagliptin and linagliptin
Sources: Andersen NB, et al
Tirzepatide is unique because it activates BOTH the GLP-1 and GIP receptors, which work together to reduce hunger, slow gastric emptying, and improve insulin sensitivity
The observed benefits in eGFR and UACR are particularly encouraging, suggesting potential for the enhanced management of kidney complications in the patient population with overweight and obesity without diabetes, Colhoun said in the press release
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Other exclusion criteria included components like alcohol consumption over a certain amount and use of GLP-1 receptor agonists in the three months leading up to screening
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