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311 Collectively, DTP cells represent an early, targetable node in resistance evolution and minimal residual disease, providing multiple intervention windows to disrupt state maintenance or bias exit trajectories toward therapeutic vulnerability
GPX was measured adding cell extract to 50 mmol/l potassium phosphate pH 7.0 containing 1 mM EDTA, 1.5 mM sodium azide, 0.15 IU of purified glutathione reductase from bakers' yeast, 0.45 mM GSH, 0.2 mM NADPH, 1.2 mM cumene hydroperoxide One unit of GPX was defined as the amount of enzyme which produces 1 mol of GSSG (oxidized glutathione)/min at 25C
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Passaia G, Queval G, Bai J, Margis-Pinheiro M, Foyer CH (2014) The effects of redox controls mediated by glutathione peroxidases on root architecture in Arabidopsis thaliana
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